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All you need to know about testosterone pellets

Testosterone pellets are a form of hormone replacement therapy. 

These pellets contain crystallized testosterone and deliver a steady, low dose of this hormone for up to six months at a time.


Benefits include increased mental and physical energy, improved libido and sexual satisfaction, a healthier physique and a better sense of well being.

A brief introduction about testosterone

Testosterone is an important hormone. It can boost libido, increase muscle mass, sharpen memory, and bump up energy. Yet, most men lose testosterone with age.

About 20 to 40 percent of older men have a medical condition called hypogonadism and need testosterone replacement therapy (TRT).


But there are drawbacks to TRT, including the potential for heart disease, high red blood cell count, and other conditions.


Successful hormone therapy involves getting just the right dose by the right delivery method for your individual needs. There are patches, creams, injections, and testosterone pellets.

What are testosterone pellets?

Bio-Identical Hormone Replacement Therapy (BHRT) is the therapeutic use of plant-based hormones that are identical on a molecular level with those created by the human body.

Hormone pellets are often the preferred method of delivery and have benefits over other formulations, such as creams or orals.

Sustained, consistent release of hormones from pellets over time is considered an advantage over the fluctuations that can occur with formulations.

Testosterone pellets are a form of hormone replacement therapy. They are about the size of a grain of rice, implanted under the skin.

These pellets contain crystallized testosterone and deliver a steady, low dose of this hormone to the individual for up to 6 months at a time.

Testosterone pellets, such as Testopel, are small. They measure 3 millimeters (mm) by 9 mm and contain crystalline testosterone.

Implanted under the skin, they slowly release testosterone over the course of three to six months.

A short, simple procedure is performed in your doctor’s office to implant the pellets under the skin, usually near your hip.

What are the benefits of testosterone pellets?

Some of the benefits of testosterone pellets include:

  • Increased mental and physical energy

  • Improved libido and sexual satisfaction

  • A healthier physique, and a better sense of well being

  • More convenient than testosterone injections

  • Causes less skin irritation than gels or creams

  • Lasts for longer with no daily medication to take

Women, in addition, may also benefit from:

  • Relief of hot flashes

  • PMS relief

  • Vaginal rejuvenation

  • Increased bone density

  • Improved sleep

Both men and women who use testosterone pellets may enjoy an array of health benefits.​ This makes sense as testosterone pellets provide hormonal balance.


Conditions of estrogen dominance, such as breast cancer, uterine fibroids, obesity, and fibromyalgia, have all been shown to be improved by T pellets.

Furthermore, natural T when delivered in a slow, and steady fashion, mimics the body’s inherent physiology, leading to minimal side effects, and superior results.

Who is an ideal candidate for testosterone pellets?

An ideal candidate is someone who is in good general health and have the following symptoms:

These symptoms can include:

  • Sluggishness

  • Decreased libido and trouble maintaining an erection

  • Loss of energy

  • Hair loss

  • An increase in body fat and decrease in muscle mass

  • Irritability and depression

Using a product such as testosterone pellets may relieve some of the symptoms associated with low testosterone levels.

What are the risks or side effects of testosterone pellets?

Although testosterone replacement therapy can be beneficial, it can cause side effects and increase the risk of certain health conditions.

The possible risks or side effects of testosterone replacement therapy may include the following:

  • Increased red blood cell production

  • Fluid retention

  • Infection of the insertion site

  • Acne

  • Oily skin

  • Decreased urine stream

  • Increased frequency of urination

  • Smaller testicle size

  • Reduced sperm count

  • New or worsening sleep apnea

  • Swelling of breast tissue and prostate

The side effects of testosterone pellets are more related to incorrect dosage. A board-certified specialist and a proper lab test decreases the potential side effects of the treatment.

Harvard Men’s Health advises people considering testosterone therapy to consult a doctor and learn about all of the side effects and risks before making a decision.

They also recommend that people interested in this therapy try to boost their energy by making lifestyle changes first.

Are testosterone pellets FDA approved?

Testosterone is FDA-approved as replacement therapy only for men who have low testosterone levels due to disorders of the testicles, pituitary gland, or brain that cause hypogonadism (FDA, 2015).

For women​, the use of testosterone pellets is considered “off-label” use.

Off-label drug use means a drug that’s been approved by the U.S. Food and Drug Administration (FDA) for one purpose is used for a different purpose that hasn’t been approved.

However, a doctor can still use the drug, because the FDA regulates the testing and approval of drugs, but not how doctors use drugs to treat their patients. So, your doctor can prescribe a drug if they believe is best for your care.

What are the requirements for testosterone pellets therapy?

A comprehensive blood panel is required and can be discussed with your healthcare provider.

For women, many physicians require that you have a current Mammogram and Pat Test (Smear).

Ask your anti-aging doctor for a total list of medical requirements you need for testosterone pellets therapy.

How is the testosterone pellets therapy like?

One week before the procedure, your antiaging doctor may advise you to stop taking blood thinners such as NSAIDs, aspirin, ibuprofen, acetaminophen, naproxen sodium, etc.

If you are required to take any of these on a daily basis, you should consult with your physician.

No fasting in advance of the procedure is required.

There is a first appointment to test your hormone levels.

Your testosterone pellets provider will then schedule an appointment to review your test results and subcutaneously insert your customized pellet therapy dosage.

During the in-office visit, patients are taken into the exam room where the insertion site is cleaned and numbed.

The most common site of insertion is the upper buttock. Once numbed, a small incision is made for the pellets to be inserted.


After the pellets are placed, the insertion site is covered with a small bandage.

Implantation is a simple procedure that typically takes only 15 minutes.

Typically, 10 to 12 pellets are implanted during the procedure.

After the procedure, you should resume your regular activities unless your doctor suggests otherwise.


Within seven to 10 days after your pellet insertion, you might experience positive changes in the therapy.

Testosterone pellet insertion is fast and simple.

Is testosterone pellets therapy painful?

Testosterone pellets is a procedure that takes less than 15 minutes and is relatively painless.

How long do testosterone pellets therapy last?

These pellets are a long-acting form of testosterone therapy.

They should deliver a stable, steady dose of testosterone, typically providing the needed level of hormone for three to four months in women and five to six months in men. 

Most patients begin to feel a big difference in seven to ten days after insertion of their first pellet, and full optimization may take up to 6 months.

The pellets do not need to be removed. They completely dissolve on their own.

What is the recovery time of testosterone pellets?

Every patient and their hormone optimization journey are unique.

After pellet insertion, extraneous exercise is not recommended and is best to eliminate lower body exercise, except walking.

Swimming, hot tubs, and bathtubs should be avoided.

You can shower 24 hours following the procedure.

After removal of the bandage, normal activities may resume.

For more specific questions about exercising, consult your healthcare provider.

What should I expect after testosterone pellets insertion?

Each patient’s experience is unique.

Once the pellets are inserted in the gluteal area, a consistent dose of hormones enters the bloodstream.

Most patients report some symptom relief in as little as 2-4 weeks, but full optimization may take up to 6 months.

Your healthcare provider will customize your hormone optimization treatment for you based on your symptoms and blood work.

Since the pellets are Bio-Identical and contain nothing other than the hormone your body naturally produces, the pellets are completely dissolved and absorbed, leaving nothing behind.

Testosterone pellets are a long-term commitment. They may require at least two visits per year.

Diet, exercise, and optimal supplementation are key for this therapy.

How much do testosterone pellets cost?

The average cost of pellets of a male pellet insertion is approximately $1,300 dollars. 

In the Dominican Republic, the cost of testosterone pellets for men is 850 dollars and 350 dollars for women.

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